Pulmonary arterial reactivity during induced infection of single lung allografts☆ | Zendy

Hae Kyoon Kim | Zendy; Vinay Rao | Zendy; Young-Sik Park | Zendy; Virginia M. Miller | Zendy; Henry D. Tazelaar | Zendy; Christopher G.A. McGregor | Zendy

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Pulmonary arterial reactivity during induced infection of single lung allografts☆

Author(s) -

Hae Kyoon Kim,

Vinay Rao,

Young-Sik Park,

Virginia M. Miller,

Henry D. Tazelaar,

Christopher G.A. McGregor

Publication year - 2007

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.11.051

Subject(s) - lung transplantation , medicine , lung , endothelin receptor , pulmonary hypertension , nitric oxide , endothelium , transplantation , pulmonary artery , pharmacology , anesthesia , receptor

Infection is a major cause of mortality in the first year following single lung transplantation and is a distinct risk factor for the development of obliterative bronchiolitis. However, little is known about changes in pulmonary vascular activity in the setting of infection, which might affect and limit function of the graft. Therefore, the aim of this study was to determine how acute infection altered pulmonary arterial reactivity in single lung allografts. Such information could help to develop better diagnostic and therapeutic targets to improve outcome when grafts become infected.

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