Reduced myocardial expression of calcium handling protein in patients with severe chronic mitral regurgitation☆☆☆ | Zendy

P Leszek | Zendy; J Korewicki | Zendy; Anna Klisiewicz | Zendy; Jadwiga Janas | Zendy; Andrzej Biederman | Zendy; Aldona Browarek | Zendy; D. Charlemagne | Zendy; Pascal Trouvé | Zendy

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Reduced myocardial expression of calcium handling protein in patients with severe chronic mitral regurgitation☆☆☆

Author(s) -

P Leszek,

J Korewicki,

Anna Klisiewicz,

Jadwiga Janas,

Andrzej Biederman,

Aldona Browarek,

D. Charlemagne,

Pascal Trouvé

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.07.008

Subject(s) - cardiology , medicine , mitral regurgitation , regurgitation (circulation) , protein expression , functional mitral regurgitation , calcium , biology , heart failure , gene , biochemistry , ejection fraction

Left ventricle (LV) function was shown to be a principal determinant of morbidity and mortality in both uncorrected and surgically corrected mitral regurgitation (MR). However, the cellular mechanisms that develop in the LV remodeling secondary to volume overload in chronic severe MR is still not well defined. In single ventricular myocyte, a reduced contraction and slowed relaxation have been mainly attributed to defective intracellular Ca2+ currents. Between several Ca2+ handling proteins, sarcoplasmic reticulum Ca2+-ATPase 2 (SERCA2) expression and activity determines not only the extent and rate of relaxation, but also the rate and amplitude of contraction. The aim of the study was to determine whether modifications of SERCA2 gene expression occurs in LV wall remodeling process secondary to chronic severe MR.

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