Effects of nicorandil preconditioning on membrane dystrophin | Zendy

Takahiro Shojima | Zendy; N HAYASHIDA | Zendy; Akinori Nishi | Zendy; Kiyoshi Takagi | Zendy; Hajime Hori | Zendy; Kenji Yoshikawa | Zendy; Shinobu Aoyagi | Zendy

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Effects of nicorandil preconditioning on membrane dystrophin

Author(s) -

Takahiro Shojima,

N HAYASHIDA,

Akinori Nishi,

Kiyoshi Takagi,

Hajime Hori,

Kenji Yoshikawa,

Shinobu Aoyagi

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.06.011

Subject(s) - nicorandil , medicine , chemistry , pharmacology , cardiology

Dystrophin is an integral membrane protein that stabilizes the sarcolemmal membrane integrity, and its loss may be involved in the mechanism of ischemia and reperfusion injury. It has been reported that ischemic preconditioning is related to the preservation of membrane dystrophin during ischemia and reperfusion. Preconditioning with nicorandil, a mitochondrial K(ATP) channel opener, may attenuate the injury by preventing a disturbance in the level of this membrane-associated protein.

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