Pravastatin prolongs graft survival in an allogeneic rat model of orthotopic single lung transplantation☆ | Zendy

Y LI | Zendy; T. David Koster | Zendy; C. Mörike | Zendy; S VHORSTEN | Zendy; Ulrich Martin | Zendy; Michael Bäder | Zendy; A HAVERICH | Zendy; Amparo Querol | Zendy

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Pravastatin prolongs graft survival in an allogeneic rat model of orthotopic single lung transplantation☆

Author(s) -

Y LI,

T. David Koster,

C. Mörike,

S VHORSTEN,

Ulrich Martin,

Michael Bäder,

A HAVERICH,

Amparo Querol

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.03.072

Subject(s) - pravastatin , transplantation , cd8 , lung transplantation , peripheral blood mononuclear cell , il 2 receptor , medicine , flow cytometry , immunology , andrology , t cell , immune system , pharmacology , biology , in vitro , biochemistry , cholesterol

MHC class II molecules play central roles in immune recognition and rejection. As statins have been shown to inhibit the production of these molecules, we analyzed the possible immunosuppressive effect of pravastatin, using our rat model of orthotopic lung transplantation.

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