Hyporesponsiveness of T cell subsets after cardiac surgery: a product of altered cell function or merely a result of absolute cell count changes in peripheral blood? | Zendy

Andreas Franke | Zendy; Wolfgang Lante | Zendy; Edmond Kurig | Zendy; Lothar Zöller | Zendy; C WEINHOLD | Zendy; Andreas Markewitz | Zendy

Open Access

Hyporesponsiveness of T cell subsets after cardiac surgery: a product of altered cell function or merely a result of absolute cell count changes in peripheral blood?

Author(s) -

Andreas Franke,

Wolfgang Lante,

Edmond Kurig,

Lothar Zöller,

C WEINHOLD,

Andreas Markewitz

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.03.029

Subject(s) - peripheral blood , cell , t cell , peripheral , medicine , immunology , biology , immune system , biochemistry

The activity of the specific immune system and especially the function of T helper (TH) cells are reduced after cardiac surgery. This decrease is followed by an increase in TH2 cell activity and a delayed recovery of TH1 cell function (TH1/TH2 shift). Neither the underlying cause nor the relationship between the absolute numbers of T lymphocyte subpopulations, the state of activation of these cells and cytokine synthesis in cell culture has been clarified. We conducted a prospective study in order to test the hypothesis that the decrease in specific immunity is not caused by dilution effects but by functional alterations in T cell subsets.

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