Open AccessP38 mitogen-activated protein kinase inhibition attenuates pulmonary inflammatory response in a rat cardiopulmonary bypass model
Author(s) -
Xiaonan Dong,
Yang Liu,
Mingyuan Du,
Qing Wang,
ChongJen Yu,
Xing Fan
Publication year - 2006
Publication title -
european journal of cardio-thoracic surgery
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1016/j.ejcts.2006.02.040
Subject(s) - cardiopulmonary bypass , p38 mitogen activated protein kinases , medicine , proinflammatory cytokine , tumor necrosis factor alpha , protein kinase a , lung , inflammation , pharmacology , kinase , anesthesia , immunology , biology , biochemistry
Cardiopulmonary bypass (CPB) produces an inflammatory response associated with pulmonary dysfunction. P38 mitogen-activated protein kinase (P38MAPK) have been shown to mediate pulmonary inflammatory response after CPB, we examined the effect of SB203580, a specific p38 MAPK inhibitor, on CPB-induced pulmonary inflammatory response.
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