Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium☆ | Zendy

Munir Boodhwani | Zendy; Jun Feng | Zendy; Shigetoshi Mieno | Zendy; Basel Ramlawi | Zendy; Neel R. Sodha | Zendy; Richard Clements | Zendy; Frank W. Sellke | Zendy

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Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium☆

Author(s) -

Munir Boodhwani,

Jun Feng,

Shigetoshi Mieno,

Basel Ramlawi,

Neel R. Sodha,

Richard Clements,

Frank W. Sellke

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.02.024

Subject(s) - contractility , coronary occlusion , occlusion , medicine , microvessel , ischemia , cardiology , chemistry , angiogenesis

Vascular occlusion during off-pump coronary surgery often results in sub-optimal visualization and endothelial damage of the target vessel. We have previously reported the safety of purified poloxamer 407, a gel with reverse thermosensitive properties, in a model of off-pump coronary occlusion. The aim of this study was to evaluate different gel concentrations and their effects on coronary occlusion time, myocardial contractility, endothelial function, and markers of myocardial injury and apoptosis.

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