Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation☆ | Zendy

David Healy | Zendy; R. William G. Watson | Zendy; Conor O’Keane | Zendy; Jim Egan | Zendy; James F. McCarthy | Zendy; John P. Hurley | Zendy; John M. Fitzpatrick | Zendy; Alfred E. Wood | Zendy

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Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation☆

Author(s) -

David Healy,

R. William G. Watson,

Conor O’Keane,

Jim Egan,

James F. McCarthy,

John P. Hurley,

John M. Fitzpatrick,

Alfred E. Wood

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.01.065

Subject(s) - medicine , integrin alpha m , transplantation , infiltration (hvac) , biopsy , immunosuppression , pathology , myeloperoxidase , heart transplantation , flow cytometry , immunology , inflammation , physics , thermodynamics

Transplant rejection remains a clinical problem despite therapies that focus on lymphocyte suppression, with little attention focused on the neutrophil. Neutrophils are however the first leukocyte to infiltrate the allograft, are capable of causing myocardial damage and may facilitate lymphocytes recruitment. We hypothesised that an early allograft neutrophil infiltration influences rejection severity.

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