Gene transfer of soluble interleukin-17 receptor prolongs cardiac allograft survival in a rat model☆ | Zendy

Jianping Li | Zendy; Eleonora Simeoni | Zendy; Sylvain Fleury | Zendy; Jean Dudler | Zendy; Emma Fiorini | Zendy; Lukas Kappenberger | Zendy; ­Ludwig K. von Segesser | Zendy; Giuseppe Vassalli | Zendy

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Gene transfer of soluble interleukin-17 receptor prolongs cardiac allograft survival in a rat model☆

Author(s) -

Jianping Li,

Eleonora Simeoni,

Sylvain Fleury,

Jean Dudler,

Emma Fiorini,

Lukas Kappenberger,

Ludwig K. von Segesser,

Giuseppe Vassalli

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.01.052

Subject(s) - cytokine , proinflammatory cytokine , antibody , transplantation , receptor , tumor necrosis factor alpha , heart transplantation , immunology , interleukin , genetic enhancement , medicine , biology , inflammation , gene , biochemistry

Interleukin-17 (IL-17), a potent proinflammatory cytokine, has been implicated in allograft rejection. We analyzed the efficacy of an adenoviral vector expressing an IL-17 inhibitor in delaying acute allograft rejection in a rat model of heart transplantation, and the biological mechanisms underlying the protective effect.

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