Differential, time-dependent effects of perivenous application of fibrin glue on medial thickening in porcine saphenous vein grafts☆ | Zendy

Song Wan | Zendy; Ahmed A. Arifi | Zendy; Mcw Chan | Zendy; Johnson H.Y. Yip | Zendy; Calvin S.H. Ng | Zendy; Louis T.C. Chow | Zendy; Anthony P.C. Yim | Zendy; Jamie Y. Jeremy | Zendy

Open Access

Differential, time-dependent effects of perivenous application of fibrin glue on medial thickening in porcine saphenous vein grafts☆

Author(s) -

Song Wan,

Ahmed A. Arifi,

Mcw Chan,

Johnson H.Y. Yip,

Calvin S.H. Ng,

Louis T.C. Chow,

Anthony P.C. Yim,

Jamie Y. Jeremy

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2005.12.059

Subject(s) - fibrin glue , medicine , proliferating cell nuclear antigen , ex vivo , vein , artery , fibrin , surgery , anatomy , in vivo , pathology , immunohistochemistry , biology , microbiology and biotechnology , immunology

Neointimal and medial thickening play a critical role in late vein graft failure following CABG. Previous ex vivo experiment suggested that perivenous application of fibrin glue may reduce the damage in the circular smooth muscle cell layer of the media of the vein graft shortly after exposing to arterial pressure. However, the in vivo as well as the longer term impact of this intervention remain unknown.

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