MCI-186 (edaravone), a free radical scavenger, attenuates ischemia–reperfusion injury and activation of phospholipase A2 in an isolated rat lung model after 18h of cold preservation | Zendy

Yusimí Reyes | Zendy; Takehiko Shimoyama | Zendy; Hideki Akamatsu | Zendy; M Sunamori | Zendy

Open Access

MCI-186 (edaravone), a free radical scavenger, attenuates ischemia–reperfusion injury and activation of phospholipase A2 in an isolated rat lung model after 18h of cold preservation

Author(s) -

Yusimí Reyes,

Takehiko Shimoyama,

Hideki Akamatsu,

M Sunamori

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2005.12.005

Subject(s) - edaravone , free radical scavenger , bronchoalveolar lavage , chemistry , extravasation , pharmacology , lung , phospholipase a2 , lipid peroxidation , reperfusion injury , ischemia , oxidative stress , anesthesia , medicine , immunology , biochemistry , enzyme

Increased microvascular permeability and extravasation of inflammatory cells are key events in ischemia-reperfusion (IR) injury. We hypothesized that edaravone, a free radical scavenger, is able to attenuate IR lung injury by decreasing oxidative stress and phospholipase A(2) (PLA(2)) activation, which otherwise may lead to lung injury through PAF receptor (PAF-R) activation.

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