Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation | Zendy

Takehiko Shimoyama | Zendy; Noriyuki Tabuchi | Zendy; Katsuo Kojima | Zendy; Hideki Akamatsu | Zendy; Hirokuni Arai | Zendy; Hiroyuki Tanaka | Zendy; Makoto Sunamori | Zendy

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Aprotinin attenuated ischemia–reperfusion injury in an isolated rat lung model after 18-hours preservation

Author(s) -

Takehiko Shimoyama,

Noriyuki Tabuchi,

Katsuo Kojima,

Hideki Akamatsu,

Hirokuni Arai,

Hiroyuki Tanaka,

Makoto Sunamori

Publication year - 2005

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2005.06.038

Subject(s) - aprotinin , reperfusion injury , lung , medicine , ischemia , anesthesia , lung transplantation , ulinastatin , edema , extravasation , pharmacology , immunology

Ischemia-reperfusion injury is a major factor in the early phase of lung transplantation. We hypothesized that aprotinin, a nonspecific serine protease inhibitor, attenuates ischemia-reperfusion lung injury by inhibiting the inflammatory response and suppressing NADPH oxidase.

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