Pre-treatment of donor with 1-deamino-8-d-arginine vasopressin could alleviate early failure of porcine xenograft in a cobra venom factor treated canine recipient☆ | Zendy

Hee Jung Kang | Zendy; Gene Lee | Zendy; Kim J | Zendy; Seung Hee Lee | Zendy; Hyun Cho Wi | Zendy; Pil Gyu Hwang | Zendy; Doo Hyun Chung | Zendy; Young Tae Kim | Zendy

Open Access

Pre-treatment of donor with 1-deamino-8-d-arginine vasopressin could alleviate early failure of porcine xenograft in a cobra venom factor treated canine recipient☆

Author(s) -

Hee Jung Kang,

Gene Lee,

Kim J,

Seung Hee Lee,

Hyun Cho Wi,

Pil Gyu Hwang,

Doo Hyun Chung,

Young Tae Kim

Publication year - 2005

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2005.02.042

Subject(s) - xenotransplantation , transplantation , medicine , von willebrand factor , pathogenesis , lung , vasopressin , platelet , lung transplantation , pulmonary hemorrhage , pulmonary hypertension , in vivo , immunology , pathology , pharmacology , biology , microbiology and biotechnology

Unlike cardiac or renal xenotransplants, the depletion of complement using cobra venom factor (CVF) does not improve pulmonary xenograft survival. Several cases suggest that the swine von Willebrand factor (vWF) may play a major role in presenting a different pathogenesis of pulmonary xenograft dysfunction from other organs. To evaluate the role of vWF and the complement system in mediating hyperacute vascular injury of pulmonary xenografts and elucidate pathogenesis of the injury, we performed swine-to-canine orthotropic single lung xenotransplantation after pre-treatment of 1-deamino-8-d-arginine vasopressin (DDAVP) and CVF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research