Anterograde versus retrograde isolated lung perfusion with melphalan in the WAG-Rij rat | Zendy

Sander Romijn | Zendy; Jeroen Hendriks | Zendy; B VANPUTTE | Zendy; Joost Weyler | Zendy; G. Guetens | Zendy; G DEBOECKG | Zendy; E A DeBruijn | Zendy; P VANSCHIL | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Anterograde versus retrograde isolated lung perfusion with melphalan in the WAG-Rij rat

Author(s) -

Sander Romijn,

Jeroen Hendriks,

B VANPUTTE,

Joost Weyler,

G. Guetens,

G DEBOECKG,

E A DeBruijn,

P VANSCHIL

Publication year - 2005

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2005.02.015

Subject(s) - lung , medicine , perfusion , melphalan , hilum (anatomy) , pulmonary artery , anesthesia , cardiology , anatomy , chemotherapy

Isolated lung perfusion (ILuP) is an experimental technique currently tested to increase the 5-year survival of 40% after surgical resection of pulmonary metastases from certain solid tumors. The standard technique of anterograde perfusion was compared with retrograde isolated lung perfusion in which the drug is introduced through the pulmonary veins while the effluent is collected from the pulmonary artery. Since the lung has a dual arterial circulation through the pulmonary artery and bronchial circulation, perfusion through the pulmonary veins can result in a more homogeneous distribution throughout the lung with subsequent higher melphalan concentration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research