Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods | Zendy

Robert W Grauss | Zendy; Mark G. Hazekamp | Zendy; F OPPENHUIZEN | Zendy; Conny J. VanMunsteren | Zendy; A GITTENBERGERDEGROOT | Zendy; Marco C. DeRuiter | Zendy

Open Access

Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods

Author(s) -

Robert W Grauss,

Mark G. Hazekamp,

F OPPENHUIZEN,

Conny J. VanMunsteren,

A GITTENBERGERDEGROOT,

Marco C. DeRuiter

Publication year - 2005

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.12.052

Subject(s) - fibronectin , extracellular matrix , laminin , glycosaminoglycan , chondroitin sulfate , chemistry , elastin , dermatan sulfate , heparan sulfate , biochemistry , tissue engineering , microbiology and biotechnology , biomedical engineering , biology , pathology , medicine

Several decellularisation techniques have been developed to produce acellular matrix scaffolds for the purpose of tissue engineering, mostly comprising (non-)ionic detergents or enzymatic extraction methods. However, the effect of chemically induced decellularisation on the major structural and adhesion molecules as well as glycosaminoglycans, and the possible replenishment of lost compounds have escaped attention.

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