Is cardiopulmonary bypass a reason for aspirin resistance after coronary artery bypass grafting? | Zendy

Nives Zimmermann | Zendy; Mustafa KURT | Zendy; A. Wenk | Zendy; Jordan M. Winter | Zendy; E GAMS | Zendy; T Hohlfeld | Zendy

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Is cardiopulmonary bypass a reason for aspirin resistance after coronary artery bypass grafting?

Author(s) -

Nives Zimmermann,

Mustafa KURT,

A. Wenk,

Jordan M. Winter,

E GAMS,

T Hohlfeld

Publication year - 2005

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.12.010

Subject(s) - cardiopulmonary bypass , bypass grafting , medicine , cardiology , artery , aspirin

'Off-pump' coronary artery bypass grafting (OPCAB) is an alternative to conventional coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB). While midterm results after OPCAB have become available, systematic studies of changes in platelet function after OPCAB are still missing. Since we have previously shown that oral aspirin treatment (100mg) does not achieve sufficient platelet inhibition in the majority of patients operated on with CPB, we hypothesized that bypass surgery without CPB (off-pump coronary artery bypass, OPCAB) causes less impairment of platelet inhibition by aspirin. The aim of this study was to investigate platelet function and the antiplatelet effect of aspirin after off-pump coronary artery bypass grafting in comparison with conventional on-pump surgery.

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