Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm | Zendy

Faraz Kerendi | Zendy

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Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm

Author(s) -

Faraz Kerendi

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.08.030

Subject(s) - wortmannin , myosin light chain kinase , vasoconstriction , vasospasm , medicine , rho associated protein kinase , endocrinology , protein kinase c , chemistry , myosin , kinase , phosphatidylinositol , biochemistry , subarachnoid hemorrhage

Current treatments for conduit vessel vasospasm are short-acting and do not inhibit all vasospastic stimuli. This study tests the hypothesis that irreversible inactivation of myosin light chain kinase provides sustained inhibition of arterial vasoconstriction stimulated by a spectrum of vasopressors.

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