?2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery | Zendy

Jason C. Jones | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

?2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery

Author(s) -

Jason C. Jones

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.08.028

Subject(s) - inotrope , cardiopulmonary bypass , medicine , anesthesia , saline , cardiology , cardiac surgery

Heart surgery is associated with impairment of the myocardial beta-adrenoceptor (betaAR) system. Effective therapies for post-operative ventricular dysfunction are limited. Prolonged inotrope exposure is associated with further betaAR down-regulation. Left ventricular (LV) dysfunction and myocardial betaAR impairment were assessed following cardiopulmonary bypass (CPB) and cardioplegic arrest in a pig model. Transfer of the human beta2-adrenoceptor transgene (Adeno-beta2AR) during cardioplegic arrest was then tested as a potential therapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research