Adenovirus-mediated overexpression of inhibitor kappa B-alpha attenuates postinfarct remodeling in the rat heart? | Zendy

Karola Trescher | Zendy

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Adenovirus-mediated overexpression of inhibitor kappa B-alpha attenuates postinfarct remodeling in the rat heart?

Author(s) -

Karola Trescher

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.07.043

Subject(s) - ejection fraction , ventricle , medicine , myocardial infarction , in vivo , cardiology , ventricular remodeling , diastole , cardiac function curve , endocrinology , ligation , heart failure , biology , blood pressure , microbiology and biotechnology

The transcription factor nuclear factor kappa B (NF-kB) plays an important role in the inflammatory response following myocardial infarction. We hypothesized that NF-kB-blockade in an animal model of acute ischemia reduces the inflammatory response and therefore attenuates ventricular remodeling.

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