Duration of action of antispasmodic agents: novel use of a mouse model as an in vivo pharmacological assay | Zendy

S Mussa | Zendy; T. Prior | Zendy; N Alp | Zendy; K. Wood | Zendy; Keith M. Chan | Zendy; David P. Taggart | Zendy

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Duration of action of antispasmodic agents: novel use of a mouse model as an in vivo pharmacological assay

Author(s) -

S Mussa,

T. Prior,

N Alp,

K. Wood,

Keith M. Chan,

David P. Taggart

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.06.018

Subject(s) - verapamil , in vivo , phenoxybenzamine , antispasmodic , pharmacology , vasoconstriction , medicine , phenylephrine , in vitro , anesthesia , chemistry , biology , calcium , blood pressure , propranolol , microbiology and biotechnology , biochemistry

Radial arteries are increasingly used as conduits for coronary artery bypass grafts, but perioperative graft vasospasm remains a concern. In vitro testing has demonstrated the efficacy of phenoxybenzamine and verapamil/nitroglycerin as topical antispasmodic agents, but their duration of action in vivo is unknown. Using an in vivo mouse model, we measured their duration of action in functioning vascular grafts, and compared this to their in vitro duration of action in ungrafted vascular segments.

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