Red blood cell aggregation during cardiopulmonary bypass: a pathogenic cofactor in endothelial cell activation? | Zendy

Aurora M. Morariu | Zendy; Yue Gu | Zendy; R C Gallandat Huet | Zendy; W Siemons | Zendy; Gerhard Rakhorst | Zendy; Wim van Oeveren | Zendy

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Red blood cell aggregation during cardiopulmonary bypass: a pathogenic cofactor in endothelial cell activation?

Author(s) -

Aurora M. Morariu,

Yue Gu,

R C Gallandat Huet,

W Siemons,

Gerhard Rakhorst,

Wim van Oeveren

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.06.010

Subject(s) - cardiopulmonary bypass , cell , cofactor , endothelial stem cell , chemistry , biochemistry , microbiology and biotechnology , medicine , cardiology , biology , enzyme , in vitro

The bio-incompatibility of the cardiopulmonary bypass (CPB) circuit and the use of artificial colloids trigger massive defense reaction that involves endothelial cells and several blood cells: platelets, neutrophils, monocytes, red blood cells (RBC) and lymphocytes. Investigating the effects on RBC aggregation and endothelial cells activation, the present study addresses two different prime solutions commonly used in the clinical practice.

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