Deleterious effects of oxygen during extracorporeal circulation for the microcirculation in vivo*1 | Zendy

Markus Kamler | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Deleterious effects of oxygen during extracorporeal circulation for the microcirculation in vivo*1

Author(s) -

Markus Kamler

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.05.045

Subject(s) - microcirculation , hyperoxia , extracorporeal circulation , intravital microscopy , venule , in vivo , superoxide dismutase , oxygenator , oxygen , chemistry , anesthesia , medicine , cardiopulmonary bypass , lung , biology , oxidative stress , microbiology and biotechnology , organic chemistry

Clinical complications arising from extracorporeal circulation (ECC) have been linked to disturbances in the microcirculation. Hyperoxia, a mainstay of supportive treatment, is clinically used for a variety of pathological states. In previous in vivo animal experiments we found increased leukocyte/endothelial (L/E) cell interaction following ECC due to oxygen derived free radicals. This study was carried out to investigate the link between arterial pO2 during ECC and the potential damage to the microcirculation, supposedly caused by oxygen derived radicals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research