Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts | Zendy

Koso Egi | Zendy; Nicole Conrad | Zendy; Jennifer Kwan | Zendy; Costas Schulze | Zendy; Richard Schulz | Zendy; Stephen M. Wildhirt | Zendy

Open Access

Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts

Author(s) -

Koso Egi,

Nicole Conrad,

Jennifer Kwan,

Costas Schulze,

Richard Schulz,

Stephen M. Wildhirt

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.04.037

Subject(s) - superoxide , nitric oxide , nitric oxide synthase , vasomotor , nitrotyrosine , superoxide dismutase , chemistry , endothelium , matrix metalloproteinase , pharmacology , medicine , endocrinology , biochemistry , enzyme

Oxidants such as nitric oxide (NO) and superoxide are involved in coronary endothelial dysfunction, an early event in the process of allograft coronary atherogenesis, possibly by activation of matrix metalloproteinases (MMPs) and extracellular matrix proteins. We investigated the contribution of inducible nitric oxide synthase (iNOS) derived NO and superoxide on (MMP)-9 activity and to changes in coronary vasomotor function in rat cardiac allografts.

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