The effect of leucodepletion on leucocyte activation, pulmonary inflammation and respiratory index in surgery for coronary revascularisation: a prospective randomised study☆ | Zendy

Christos Alexiou | Zendy; Augustine Tang | Zendy; Stuart Sheppard | Zendy; David C Smith | Zendy; Roz Gibbs | Zendy; Steven Livesey | Zendy; James L. Monro | Zendy; Marcus P. Haw | Zendy

Open Access

The effect of leucodepletion on leucocyte activation, pulmonary inflammation and respiratory index in surgery for coronary revascularisation: a prospective randomised study☆

Author(s) -

Christos Alexiou,

Augustine Tang,

Stuart Sheppard,

David C Smith,

Roz Gibbs,

Steven Livesey,

James L. Monro,

Marcus P. Haw

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.04.017

Subject(s) - medicine , cardiopulmonary bypass , oxygenation index , anesthesia , exhaled nitric oxide , mechanical ventilation , cardiac surgery , artery , cardiology , surgery , inflammation , systemic inflammation

Leucocyte activation is central to end-organ damage that occurs during cardiac surgery under cardiopulmonary bypass (CPB). Exhaled nitric oxide (NO) increases in inflammatory lung conditions and has been proposed as a marker of pulmonary inflammation during CPB. This study examined the effect of leucodepletion on leucocyte activation, pulmonary inflammation and oxygenation in patients undergoing coronary revascularisation.

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