Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response☆ | Zendy

Yoshitaka Hayashi | Zendy; Yoshiki Sawa | Zendy; Motonobu Nishimura | Zendy; Naoto Fukuyama | Zendy; Hajime Ichikawa | Zendy; Shigeaki Ohtake | Zendy; Hiroe Nakazawa | Zendy; Hikaru Matsuda | Zendy

Open Access

Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response☆

Author(s) -

Yoshitaka Hayashi,

Yoshiki Sawa,

Motonobu Nishimura,

Naoto Fukuyama,

Hajime Ichikawa,

Shigeaki Ohtake,

Hiroe Nakazawa,

Hikaru Matsuda

Publication year - 2004

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2004.03.033

Subject(s) - peroxynitrite , nitric oxide , superoxide , chemistry , cardiopulmonary bypass , nitrotyrosine , nitrite , nitric oxide synthase , pharmacology , medicine , biochemistry , nitrate , organic chemistry , enzyme

Cardiopulmonary bypass (CPB) is known to induce post-bypass systemic inflammatory response. Peroxynitrite (ONOO-) is a potent oxidant formed by a rapid reaction between nitric oxide (NO) and superoxide anion. We hypothesized that ONOO- plays a role in the development of post-bypass systemic inflammatory response and examined the efficacy of ONOO- scavenger in a rat-CPB model.

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