Does serum 25 hydroxy vitamin D level play a role in COPD?

It has been recognized that, in addition to its classical function, vitamin D modulates a variety of processes and regulatory systems including host defense, inflammation, and immunity. Some authors concluded that there is strong relation between vitamin D serum level and lung functions but others concluded that there is no relation between them.Aim of the work: To study the role of serum level of 25 hydroxy-vitamin D in COPD patients, also, assess the serum level of vitamin D dependent LL-37 and IFNγ and to study the link between the three parameters and pulmonary functions in these patients.Subjects and methods: This study was conducted on 40 persons who were divided into GI, 10 controls and GII, 30 COPD patients. FEV1, serum levels of 25 hydroxy vitamin D, LL-37 and IFNγ were measured.Results: Serum levels of 25 hydroxy vitamin D and LL-37 were significantly decreased in GII as compared to GI while serum level of IFNγ was significantly increased in GII as compared to GI and there was a significant positive correlation between vitamin D level and FEV1 and LL-37 level while there was a negative correlation between it and IFNγ level.Conclusion: Vitamin D level affects pulmonary function in COPD through its effect on LL-37 and IFNγ serum level