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AimTo detect the impact of elective PCI on left intraventricular mechanical dyssynchrony in patients with chronic stable angina.Methods100 patients with chronic stable angina were included and divided into two groups according to LV systolic and diastolic mechanical dyssynchrony measured by TSI 12-segments SD and Te-SD. 24h then 1month after PCI, patients with dyssynchrony were reclassified into improved vs persistent LV mechanical dyssynchrony.ResultsAt baseline 72% had LV systolic mechanical dyssynchrony. Patients with LV systolic mechanical dyssynchrony were significantly older (58.42±4.617 vs. 54.64±3.456, respectively, p<0.001), diabetic (36.11% vs. 14.3% p value<0.05), higher prevalence of pseudo-normal and restrictive filling patterns (p value<0.05), significantly larger LVESV (39.88±13.67 vs. 32.93±9.79ml, p<0.05), lower EF% (54.13±6.69% vs. 58.54±6.4%, p value<0.05) and greater WMSI (1.3±0.25 vs. 1.15±0.13, p value<0.05). 24h after PCI, 16 (22.22%) improved. 1m after PCI 61 (84.72%) improved from baseline. Latest activated segment improved in 21.02% after 24h and 41.69% improved after 1m. Age was only variable independently associated with non-improvement of LV systolic mechanical dyssynchrony on multivariate analysis. Of the 23 patients with normal EF and WMSI, 13 had systolic dyssynchrony at baseline, 6 improved after 24h and all improved at 1m. Diastolic dysfunction improved in 18 (28.125%) 24h after PCI. After 1m improved in 50 (78.125%) and remained unchanged in 14 (21.875%), and was closely correlated to the grades of LV diastolic dysfunction.ConclusionPCI had significant effect on LV systolic and diastolic mechanical intraventricular dyssynchrony

Impact of elective PCI on left intraventricular mechanical dyssynchrony in patients with chronic stable angina (tissue Doppler study)