The data monitoring experience in the MOXCON trial | Zendy

S J Pocock | Zendy; Lars Wilhelmsen | Zendy; Kenneth Dickstein | Zendy; G. E. Francis | Zendy; Janet Wittes | Zendy

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The data monitoring experience in the MOXCON trial

Author(s) -

S J Pocock,

Lars Wilhelmsen,

Kenneth Dickstein,

G. E. Francis,

Janet Wittes

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.09.015

Subject(s) - medicine , interim analysis , data monitoring committee , interim , placebo , randomized controlled trial , clinical endpoint , heart failure , moxonidine , clinical trial , emergency medicine , alternative medicine , receptor , archaeology , pathology , history , agonist

This article describes a challenging data monitoring experience that occurred in a major international randomized placebo-controlled trial in patients with heart failure, in which the accumulating interim data showed an excess of deaths on the active treatment.

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