Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects | Zendy

Anna FC Schut | Zendy; Gysèle S. Bleumink | Zendy; Bruno H. Stricker | Zendy; Albert Hofman | Zendy; Jacqueline C.M. Witteman | Zendy; H. A. P. Pols | Zendy; J. W. Deckers | Zendy; Jaap Deinum | Zendy; Cornelia M. van Duijn | Zendy

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Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects

Author(s) -

Anna FC Schut,

Gysèle S. Bleumink,

Bruno H. Stricker,

Albert Hofman,

Jacqueline C.M. Witteman,

H. A. P. Pols,

J. W. Deckers,

Jaap Deinum,

Cornelia M. van Duijn

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.08.026

Subject(s) - medicine , heart failure , angiotensin converting enzyme , rotterdam study , cardiology , genotype , left ventricular hypertrophy , population , endocrinology , incidence (geometry) , prospective cohort study , blood pressure , genetics , physics , environmental health , biology , optics , gene

Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects.

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