C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease | Zendy

Stephan Fichtlscherer | Zendy; S. Breuer | Zendy; Volker Schächinger | Zendy; Stefanie Dimmeler | Zendy; Andreas M. Zeiher | Zendy

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C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease

Author(s) -

Stephan Fichtlscherer,

S. Breuer,

Volker Schächinger,

Stefanie Dimmeler,

Andreas M. Zeiher

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.06.026

Subject(s) - medicine , bioavailability , coronary artery disease , nitric oxide , cardiology , disease , c reactive protein , pharmacology , inflammation

Elevated C-reactive protein (CRP) levels are associated with impaired endothelial vasoreactivity in patients with coronary artery disease (CAD). Because inflammatory cytokines experimentally reduce basal and stimulated endothelial nitric oxide (NO) release, we hypothesised that patients with elevated CRP-levels are characterised by a systemic impairment in NO bioavailability.

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