Role of ?1- and ?2-adrenoceptor polymorphisms in heart failure: a case-control study | Zendy

Loredana Covolo | Zendy; Umberto Gelatti | Zendy; Marco Metra | Zendy; S NODARI | Zendy; Antonio Piccichè | Zendy; Natalia Pezzali | Zendy; Claudia Zani | Zendy; Adriana Alberti | Zendy; Francesco Donato | Zendy; Giuseppe Nardi | Zendy

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Role of ?1- and ?2-adrenoceptor polymorphisms in heart failure: a case-control study

Author(s) -

Loredana Covolo,

Umberto Gelatti,

Marco Metra,

S NODARI,

Antonio Piccichè,

Natalia Pezzali,

Claudia Zani,

Adriana Alberti,

Francesco Donato,

Giuseppe Nardi

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.06.015

Subject(s) - medicine , heart failure , pathogenesis , adrenergic receptor , gene , case control study , endocrinology , genetics , receptor , biology

We hypothesised that the polymorphisms of the genes encoding for beta1- and the beta2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the beta1-adrenoceptor gene (Arg389Gly), the beta2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area.

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