Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent | Zendy

Felix Vogt | Zendy

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Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent

Author(s) -

Felix Vogt

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.06.010

Subject(s) - paclitaxel , medicine , stent , restenosis , biodegradable polymer , stenosis , coronary arteries , balloon catheter , biocompatibility , biomedical engineering , balloon , surgery , artery , polymer , materials science , chemotherapy , metallurgy , composite material

The aim of this study was to assess technical feasibility, biocompatibility, and impact on coronary stenosis of a new biodegradable paclitaxel-loaded polylactide stent. Due to high rates of in-stent restenosis and permanent nature of metal stent implants, synthetic polymers have been proposed as surrogate materials for stents and local delivery systems for drugs. Paclitaxel was shown to inhibit vascular smooth muscle cell proliferation and migration.

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