Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis | Zendy

Eleonora Simeoni | Zendy

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Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis

Author(s) -

Eleonora Simeoni

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.05.005

Subject(s) - medicine , coronary artery disease , gastroenterology , chemokine , fibrinogen , genotype , immunology , inflammation , gene , biology , biochemistry

Polymorphisms in the RANTES (G-403A), monocyte chemoattractant protein-1 (MCP-1; A-2518G), stromal cell-derived factor-1beta (SDF-1beta; G801A), and C-C chemokine receptor-5 (CCR5; Delta32) genes have been associated with functional effects. These chemokines have been implicated in leucocyte recruitment to arterial lesions. In a case-control study, we explored relations between these polymorphisms and coronary artery disease (CAD), with respect to angiographic abnormalities and acute coronary syndromes (ACS).

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