No evidence for a reduction of myocardial infarctions by acarbose | Zendy

F VANDELAAR | Zendy

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No evidence for a reduction of myocardial infarctions by acarbose

Author(s) -

F VANDELAAR

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2004.01.026

Subject(s) - acarbose , medicine , reduction (mathematics) , myocardial infarction , cardiology , endocrinology , diabetes mellitus , geometry , mathematics

With great interest we read the article of Hanefeld et al., in which a meta-analysis of seven randomised controlled trials was presented. This meta-analysis compared acarbose with placebo in patients with type 2 diabetes with respect to the incidence of cardiovascular events.1 The conclusion that acarbose can prevent myocardial infarctions surprised us because, currently finishing a Cochrane systematic review on the topic,2 we found only scarce outcomes regarding diabetes-related morbidity so far. Moreover, we were very disappointed that the design and conduct of this study was not critically discussed at all, even more so because they suggest major flaws that …

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