Open Access?Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2
Author(s) -
S Dhamrait
Publication year - 2004
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1016/j.ehj.2004.01.007
Subject(s) - oxidative stress , diabetes mellitus , medicine , endocrinology , genotype , obesity , allele , reactive oxygen species , antioxidant , gene , genetics , biology , biochemistry
Oxidative stress reduces total antioxidant status (TAOS) and is implicated in atherogenesis. Mitochondrial uncoupling protein 2 (UCP2) negatively regulates reactive oxygen species generation. The UCP2 gene demonstrates a common functional promoter variant (-866G>A).
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