Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population | Zendy

AnnaLena Eriksson | Zendy

Open Access

Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population

Author(s) -

AnnaLena Eriksson

Publication year - 2004

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1016/j.ehj.2003.12.026

Subject(s) - medicine , myocardial infarction , catechol o methyl transferase , genotype , cardiology , population , peptidyl dipeptidase a , association (psychology) , genetics , angiotensin converting enzyme , blood pressure , environmental health , gene , biology , philosophy , epistemology

Estrogens regulate several biological processes involved in the pathogenesis of myocardial infarction. Catechol-O-methyltransferase (COMT) is a key enzyme in the degradation of estrogens. There is a functional polymorphism in the COMT gene (Val158Met), affecting the activity of the enzyme. We investigated if the low activity genotype of COMT is associated with an altered risk of myocardial infarction.

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