Synthesis and Characterization of Nano-encapsulated Drug Delivery System for Bone Loss | Zendy

Qingwen Ni | Zendy; Hong Dixon | Zendy; YiXian Qin | Zendy

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Synthesis and Characterization of Nano-encapsulated Drug Delivery System for Bone Loss

Author(s) -

Qingwen Ni,

Hong Dixon,

YiXian Qin

Publication year - 2011

Publication title -

energy procedia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.474

H-Index - 81

ISSN - 1876-6102

DOI - 10.1016/j.egypro.2011.10.604

Subject(s) - publishing , library science , drug delivery , nano , characterization (materials science) , engineering , nanotechnology , computer science , materials science , political science , law , chemical engineering

A formulation of nano-encapsulated enantiomer of (+)promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR), and xray techniques to qualitatively evaluate the effectiveness of the new bone formations. Our studies suggest that nanoencapsulated (+)promethazine in controlled release formulations are effective in promoting bone growth in a rat model. Conjugating bone-targeting functional groups to the nanoparticles further enhances the efficacy of the drug. Keywords-nano-encapsulation, bone, NMR

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