Open AccessPrognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort
Author(s) -
Pedro David WendelGarcia,
Thierry Fumeaux,
Philippe Guerci,
Dorothea M. Heuberger,
Jonathan Montomoli,
Ferran RocheCampo,
Reto Andreas Schuepbach,
Matthias P. Hilty,
Mario Alfaro Farias,
Antoni Margarit,
Gerardo Vizmanos-Lamotte,
Thomas Tschoellitsch,
Jens Meier,
Francesco Cardona,
Josef Škola,
Lenka Horáková,
Hernan AguirreBermeo,
Janina Apolo,
Emmanuel Novy,
Marie-Reine Losser,
Geoffrey Jurkolow,
Gauthier Delahaye,
Sascha David,
Tobias Welte,
Tobias Wengenmayer,
Dawid L. Staudacher,
Theodoros Aslanidis,
Barna Babik,
Anita Korsós,
János Gál,
Hermann Csaba,
Abele Donati,
Andrea Carsetti,
F Turrini,
Maria Sole Simonini,
Roberto Ceriani,
Martina Murrone,
Emanuele Rezoagli,
Giovanni Vitale,
Alberto Fogagnolo,
Savino Spadaro,
Maddalena Alessandra Wu,
Chiara Cogliati,
Riccardo Colombo,
E Catena,
Francesca Facondini,
Antonella Potalivo,
Gianfilippo Gangitano,
Tiziana Perin,
Maria Grazia Bocci,
Massimo Antonelli,
Diederik Gommers,
Alper Can İnce,
Eric Mayor-Vázquez,
María Cruz,
M. Cruz Martín Delgado,
Raquel Rodriguez Garcia,
Jorge Gámez Zapata,
Begoña Zalba-Etayo,
Herminia Lozano-Gómez,
Pedro Castro,
Adrián Téllez,
Adriana Jacas,
Guido Muñoz,
Rut Andrea,
Jose T. OrtizPérez,
Eduard Quintana,
Irene Rovira,
Enric Reverter,
Javier Fernández,
Miquel Ferrer,
Joan R. Badia,
Arantxa Lander Azcona,
Jesús Escos Orta,
Philipp Bühler,
Silvio D. Brugger,
Daniel A. Hofmaenner,
Simone Unseld,
Frank Ruschitzka,
Mallory MoretBochatay,
Bernd Yuen,
Thomas Hillermann,
Hatem Ksouri,
Govind Sridharan,
Anette Ristic,
Michael Sepulcri,
Miodrag Filipovic,
Urs Pietsch,
Petra Salomon,
Iris Drvaric,
Peter Schott,
Severin Urech,
Adriana Lambert,
Lukas Merki,
Marcus Laube,
Frank Hillgaertner,
Marianne Sieber,
Alexander Dullenkopf,
Lina Petersen,
Serge Grazioli,
Peter C. Rimensberger,
Isabelle Fleisch,
Jerôme Lavanchy,
Katharina Marquardt,
Karim Shaikh,
Hermann Redecker,
Michael Stephan,
Jan Brem,
Bjarte Rogdo,
André Birkenmaier,
Friederike Meyer zu Bentrup,
Patricia Fodor,
Pascal Locher,
Giovanni Camen,
Martin Siegemund,
Núria Zellweger,
MarieMadlen Jeitziner,
Béatrice JenniMoser,
Christian Bürkle,
GianReto Kleger,
Marilene Franchitti Laurent,
Jean-Christophe Laurent,
Tomislav Gaspert,
Marija Jović,
Michael Studhalter,
Christoph Haberthuer,
Roger F. Lussman,
Daniela Selz,
Didier Naon,
Romano Mauri,
Samuele Ceruti,
Julien Marrel,
Mirko Brenni,
Rolf Ensner,
Nadine Gehring,
Antje Heise,
Tobias Huebner,
Thomas A. Neff,
Sara Cereghetti,
Filippo Boroli,
Jérôme Pugin,
Nandor Marczin,
Joyce Wong
Publication year - 2020
Publication title -
eclinicalmedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.915
H-Index - 20
ISSN - 2589-5370
DOI - 10.1016/j.eclinm.2020.100449
Subject(s) - medicine , intensive care unit , ards , hazard ratio , apache ii , mechanical ventilation , proportional hazards model , intensive care , emergency medicine , intensive care medicine , confidence interval , lung
The European RISC-19-ICU cohort demonstrates a moderate mortality of 24% in critically ill patients with COVID-19. Despite high ARDS severity, mechanical ventilation incidence was low and associated with more rescue therapies. In contrast to risk factors in hospitalized patients reported in other studies, the main mortality predictors in these critically ill patients were markers of oxygenation deficit, renal and microvascular dysfunction, and coagulatory activation. Elevated risk of bloodstream infections underscores the need to exercise caution with off-label therapies.
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