Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma | Zendy

Yuh-Feng Lin | Zendy; JianLiang Chou | Zendy; JengShou Chang | Zendy; IJen Chiu | Zendy; HuiWen Chiu | Zendy; YuanFeng Lin | Zendy

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Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma

Author(s) -

Yuh-Feng Lin,

JianLiang Chou,

JengShou Chang,

IJen Chiu,

HuiWen Chiu,

YuanFeng Lin

Publication year - 2019

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2019.06.006

Subject(s) - clear cell renal cell carcinoma , downregulation and upregulation , gene knockdown , cancer research , metastasis , microrna , biology , immunohistochemistry , cell growth , cell migration , cancer , medicine , pathology , cell , cell culture , renal cell carcinoma , biochemistry , genetics , gene

We conclude that miR-25-mediated IMPA2 downregulation constitutes a novel signature for cancer metastasis and poor outcomes in ccRCC. We further postulate that the therapeutic targeting of miR-25 can be useful for preventing the metastatic progression of ccRCC associated with IMPA2 downregulation. FUND: This study was supported by the Ministry of Science and Technology, Taiwan (MOST 107-2314-B-038-094, MOST 106-2314-B-038-069-MY3, MOST 105-2320-B-038-021-MY3 and MOST 107-2320-B-038-056).

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