Open AccessNCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways
Author(s) -
Fanzheng Meng,
Shugeng Zhang,
Ruipeng Song,
Yao Liu,
Jiabei Wang,
Yingjian Liang,
Jizhou Wang,
Jihua Han,
Xuan Song,
Zhaoyang Lu,
Guangchao Yang,
Shangha Pan,
Xianying Li,
Yufeng Liu,
Fang Zhou,
Yan Wang,
Yifeng Cui,
Bo Zhang,
Kun Ma,
Congyi Zhang,
Yufei Sun,
Mengyang Xin,
Lianxin Liu
Publication year - 2019
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2019.05.053
Subject(s) - hepatocellular carcinoma , stat3 , cancer research , metastasis , microrna , signal transduction , carcinoma , medicine , biology , pathology , cancer , microbiology and biotechnology , gene , genetics
Our study indicates that NCAPG2 overexpression could drive HCC proliferation and metastasis through activation of the STAT3 and NF-κB/miR-188-3p pathways. These findings may contribute to the identification of novel biomarkers and therapeutic targets for HCC. FUND: National Key Program for Science and Technology Research and Development (Grant No. 2016YFC0905902); the National Natural Scientific Foundation of China (Nos. 81772588, 81602058, 81773194); University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (Grant No. UNPYSCT-2016200); the Innovative Research Program for Graduate of Harbin Medical University (Grant Nos. YJSCX2017-38HYD, YJSCX2016-18HYD).
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