International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact | Zendy

Rebecca A. Gladstone | Zendy; Stephanie W. Lo | Zendy; John A. Lees | Zendy; Nicholas J. Croucher | Zendy; Andries J. van Tonder | Zendy; Jukka Corander | Zendy; Andrew J. Page | Zendy; Pekka Marttinen | Zendy; Leon J. Bentley | Zendy; Theresa J. Ochoa | Zendy; PakLeung Ho | Zendy; Mig du Plessis | Zendy; Jennifer Cornick | Zendy; Brenda Kwambana-Adams | Zendy; Rachel Benisty | Zendy; Susan Nzenze | Zendy; Shabir A. Madhi | Zendy; Paulina A. Hawkins | Zendy; Dean Everett | Zendy; Martín Antonio | Zendy; Ron Dagan | Zendy; Keith P. Klugman | Zendy; Anne von Gottberg | Zendy; Lesley McGee | Zendy; Robert F. Breiman | Zendy; Stephen D. Bentley | Zendy

Open Access

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact

Author(s) -

Rebecca A. Gladstone,

Stephanie W. Lo,

John A. Lees,

Nicholas J. Croucher,

Andries J. van Tonder,

Jukka Corander,

Andrew J. Page,

Pekka Marttinen,

Leon J. Bentley,

Theresa J. Ochoa,

PakLeung Ho,

Mig du Plessis,

Jennifer Cornick,

Brenda Kwambana-Adams,

Rachel Benisty,

Susan Nzenze,

Shabir A. Madhi,

Paulina A. Hawkins,

Dean Everett,

Martín Antonio,

Ron Dagan,

Keith P. Klugman,

Anne von Gottberg,

Lesley McGee,

Robert F. Breiman,

Stephen D. Bentley

Publication year - 2019

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2019.04.021

Subject(s) - serotype , biology , pneumococcal conjugate vaccine , multilocus sequence typing , antibiotic resistance , virology , streptococcus pneumoniae , pneumococcal infections , pneumococcal disease , carriage , antibiotics , genetics , genotype , medicine , gene , pathology

Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study pneumococcal serotype, antibiotic resistance and invasiveness, in the context of genetic background.

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