Open AccessLongitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model
Author(s) -
Usha K. Nivarthi,
Huy A. Tu,
Matthew J. Delacruz,
Jesica Swanstrom,
B. L. Patel,
Anna P. Durbin,
Stephen S. Whitehead,
Kristen K. Pierce,
Beth D. Kirkpatrick,
Ralph S. Baric,
Ngan Nguyen,
Daniel Emerling,
Aravinda M. de Silva,
Sean A. Diehl
Publication year - 2019
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2019.02.060
Subject(s) - biology , virology , memory b cell , dengue virus , antibody , epitope , immunology , b cell , serotype , monoclonal antibody , virus
Acute viral infections induce a rapid and transient increase in antibody-secreting plasmablasts. At convalescence, memory B cells (MBC) and long-lived plasma cells (LLPC) are responsible for long-term humoral immunity. Following an acute viral infection, the specific properties and relationships between antibodies produced by these B cell compartments are poorly understood.
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