PYY plays a key role in the resolution of diabetes following bariatric surgery in humans | Zendy

Claudia Guida | Zendy; Sam D. Stephen | Zendy; Michael Watson | Zendy; Niall Dempster | Zendy; Pierre Larraufie | Zendy; Thomas Marjot | Zendy; Tamsin Cargill | Zendy; Lisa Rickers | Zendy; Michael Pavlides | Zendy; Jeremy Tomlinson | Zendy; Jeremy Cobbold | Zendy; ChunMei Zhao | Zendy; Duan Chen | Zendy; Fiona M. Gribble | Zendy; Frank Reimann | Zendy; Richard Gillies | Zendy; Bruno Sgromo | Zendy; Patrik Rorsman | Zendy; John Ryan | Zendy; Reshma Ramracheya | Zendy

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PYY plays a key role in the resolution of diabetes following bariatric surgery in humans

Author(s) -

Claudia Guida,

Sam D. Stephen,

Michael Watson,

Niall Dempster,

Pierre Larraufie,

Thomas Marjot,

Tamsin Cargill,

Lisa Rickers,

Michael Pavlides,

Jeremy Tomlinson,

Jeremy Cobbold,

ChunMei Zhao,

Duan Chen,

Fiona M. Gribble,

Frank Reimann,

Richard Gillies,

Bruno Sgromo,

Patrik Rorsman,

John Ryan,

Reshma Ramracheya

Publication year - 2019

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2018.12.040

Subject(s) - medicine , endocrinology , peptide yy , islet , enteroendocrine cell , hormone , insulin , type 2 diabetes , diabetes mellitus , appetite , endocrine system , neuropeptide y receptor , receptor , neuropeptide

Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial mediators of this effect. Unlike GLP-1, the role of the hormone peptide tyrosine tyrosine (PYY) in bariatric surgery in humans has been limited to appetite regulation and its impact on pancreatic islet secretory function and glucose metabolism remains under-studied.

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