Open AccessMicro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
Author(s) -
André Varcianna,
Monika A. Myszczynska,
Lydia M. Castelli,
Brendan O’Neill,
Ye-Seul Kim,
Jordan Talbot,
Sophie Nyberg,
Immanuelle Nyamali,
Paul R. Heath,
Matthew J. Stopford,
Guillaume M. Hautbergue,
Laura Ferraiuolo
Publication year - 2019
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2018.11.067
Subject(s) - astrocyte , biology , microbiology and biotechnology , downregulation and upregulation , amyotrophic lateral sclerosis , neurodegeneration , neurite , c9orf72 , neuroscience , central nervous system , in vitro , pathology , medicine , biochemistry , trinucleotide repeat expansion , gene , allele , disease
Astrocytes regulate neuronal function, synaptic formation and maintenance partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) astrocytes display a toxic phenotype that contributes to motor neuron (MN) degeneration.
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