COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis | Zendy

Yuan Li | Zendy; Christoffer Soendergaard | Zendy; Fredrik Bergenheim | Zendy; David M. Aronoff | Zendy; Ginger L. Milne | Zendy; Lene Riis | Zendy; Jakob Benedict Seidelin | Zendy; Kim B. Jensen | Zendy; Ole Haagen Nielsen | Zendy

Open Access

COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

Author(s) -

Yuan Li,

Christoffer Soendergaard,

Fredrik Bergenheim,

David M. Aronoff,

Ginger L. Milne,

Lene Riis,

Jakob Benedict Seidelin,

Kim B. Jensen,

Ole Haagen Nielsen

Publication year - 2018

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2018.08.040

Subject(s) - tumor necrosis factor alpha , cancer research , medicine , immunology , cyclooxygenase , signal transduction , inflammatory bowel disease , proinflammatory cytokine , biology , inflammation , microbiology and biotechnology , disease , enzyme , biochemistry

Inhibition of tumor necrosis factor-α (TNF) signaling is beneficial in the management of ulcerative colitis (UC), but up to one-third of patients do not have a clinical response of relevance to TNF inhibitors during induction therapy (i.e. primary non-responders [PNRs]). Through production of prostaglandins (PGs) and thromboxanes, cyclooxygenase-2 (COX-2) affects inflammation and epithelial regeneration and may in this way be implicated in treatment resistance to TNF inhibitors.

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