Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
Author(s) -
Amy Ferguson,
Laura M. Lyall,
Joey Ward,
Rona J. Strawbridge,
Breda Cullen,
Nicholas Graham,
Claire L. Niedzwiedz,
Keira J.A. Johnston,
Daniel Mackay,
Stephany M. Biello,
Jill P. Pell,
Jonathan Cavanagh,
Andrew M. McIntosh,
Aiden Doherty,
Mark E.S. Bailey,
Donald M. Lyall,
Cathy Wyse,
Daniel J. Smıth
Publication year - 2018
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2018.08.004
Subject(s) - biobank , circadian rhythm , association (psychology) , genome wide association study , genetic association , mood , polygenic risk score , genetics , biology , medicine , psychiatry , genotype , psychology , gene , single nucleotide polymorphism , psychotherapist
Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder.
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