Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence | Zendy

Jessica K. Lee | Zendy; Amy L. Conrad | Zendy; Eric A. Epping | Zendy; Katherine D. Mathews | Zendy; Vincent A. Magnotta | Zendy; Jeffrey D. Dawson | Zendy; Peg Nopoulos | Zendy

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Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence

Author(s) -

Jessica K. Lee,

Amy L. Conrad,

Eric A. Epping,

Katherine D. Mathews,

Vincent A. Magnotta,

Jeffrey D. Dawson,

Peg Nopoulos

Publication year - 2018

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2018.03.031

Subject(s) - genetics , trinucleotide repeat expansion , huntington's disease , gene , biology , myotonic dystrophy , computational biology , medicine , allele , disease

Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeats being associated with higher cognitive function. The current study now expands this line of inquiry to evaluate the effects of CAG repeat throughout the entire spectrum of repeats from 15 to 58.

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