Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis | Zendy

Mattias Collin | Zendy

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Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis

Author(s) -

Mattias Collin

Publication year - 2017

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2017.02.008

Subject(s) - proteinase 3 , autoantibody , immunology , microscopic polyangiitis , medicine , vasculitis , antibody , anti neutrophil cytoplasmic antibody , disease , pathology

Article history: Received 9 February 2017 Accepted 9 February 2017 Available online 10 February 2017 non-relapsing patients the glycosylation profiles did not change. Somewhat surprising, PR3-ANCA galactosylation, sialylation, and fucosylation decreased in both relapsing and non-relapsing patients. It has been known for some30years now thatmanifest autoimmune disease is correlated with changes in the glycosylation of antibodies (Parekh et al., 1985), and the list of autoimmune diseases with alter-

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