Brain Correlates of Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI) | Zendy

Lisa M. James | Zendy; Brian Engdahl | Zendy; Arthur C. Leuthold | Zendy; Apostolos P. Georgopoulos | Zendy

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Brain Correlates of Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI)

Author(s) -

Lisa M. James,

Brian Engdahl,

Arthur C. Leuthold,

Apostolos P. Georgopoulos

Publication year - 2016

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2016.10.019

Subject(s) - human leukocyte antigen , allele , medicine , mood , magnetoencephalography , immunology , antigen , electroencephalography , biology , genetics , psychiatry , gene

We recently reported that six alleles from class II genes of the Human Leukocyte Antigen (HLA) confer protection from Gulf War Illness (GWI) (Georgopoulos et al., 2015). The most significant effect is exerted on Neurological-Cognitive-Mood (NCM), Pain, and Fatigue symptoms, such that higher number of copies of the protective alleles are associated with lower symptom severity. Here we tested the hypothesis that this effect is exerted by modulating the strength of neural synchronicity.

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