Open AccessGenetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects
Author(s) -
Camilla J. Kobylecki,
Shoaib Afzal,
Børge G. Nordestgaard
Publication year - 2015
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2015.11.026
Subject(s) - medicine , diabetes mellitus , hazard ratio , heart failure , population , heterozygote advantage , disease , heart disease , endocrinology , prospective cohort study , type 2 diabetes , cardiology , allele , biology , genetics , confidence interval , environmental health , gene
Hyperglycemia-induced oxidative stress is one mechanism believed to underlie diabetic vascular disease. We tested the hypothesis that diabetic subjects heterozygous for extracellular superoxide dismutase (SOD3) R213G, which entails lower antioxidant capacity in tissues, have increased risk of cardiovascular disease and heart failure.
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